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Monday 30 December 2013

Scientists discover potential drug to block AIDS

Scientists at the Gladstone Institutes have identified the precise chain of molecular events in the human body that drives the death of most of the immune system’s CD4 T cells as an HIV infection leads to AIDS.

A typical scene at an emergency ward of a Lagos State government hospital before the protracted doctors strike.

Further, they have identified an existing anti-inflammatory drug that in laboratory tests blocks the death of these cells — and now are planning a Phase 2 clinical trial to determine if this drug or a similar drug can prevent HIV-infected people from developing AIDS.

Two separate journal articles, published simultaneously in Nature and Science, detail the research from the laboratory of Dr. Warner C. Greene, who directs virology and immunology research at Gladstone, an independent biomedical-research nonprofit.

His lab’s Science paper reveals how, during an HIV infection, a protein known as IFI16 senses fragments of HIV DNA in abortively infected immune cells.

This triggers the activation of the human enzyme caspase-1 and leads to pyroptosis, a fiery and highly inflammatory form of cell death.As revealed in Nature, this repetitive cycle of abortive infection, cell death, inflammation and recruitment of additional CD4 T cells to the infection “hot zone” ultimately destroys the immune system and causes AIDS.

“Gladstone has showed how the body’s own immune response to HIV causes CD4 T cell death via a pathway triggering inflammation, and secondly by identifying the host DNA sensor that detects the viral DNA and triggers this death response,” said Dr. Robert F.Siliciano, a professor of medicine at Johns Hopkins University, and a Howard Hughes Medical Institute investigator.
“This one-two punch of discoveries underscores the critical value of basic science — by uncovering the major cause of CD4 T cell depletion in AIDS, Dr. Greene’s lab has been able to identify a potential new therapy for blocking the disease’s progression and improving on current antiretroviral medications.”



#vanguard

Update: Michael Schumacher in coma after brain operation as surgeons battle to save his life



Schumacher is still fighting for his life in an induced coma.
The seven-time F1 world champion has had one operation, which removed clots on the brain.
Doctors say they are working hour-by-hour and are unwilling to give any more information.
They did say, however, he wouldn't have survived without a helmet.

Let's put him in prayers and hope for the best!

Sunday 29 December 2013

Racing legend Michael Schumacher fighting for his life in intensive care following a horrific skiing accident

Former F1 Driver Michael Schumacher Hurt In Skiing Accident



Formula I motor racing legend Michael Schumacher was fighting for his life in intensive care tonight following a horrific skiing accident.

The 44-year-old's head hit a rock following an off-piste fall in the French Alpine resort of Meribel on Sunday morning.


An emergency evacuation airlifted Schumacher off the slopes by helicopter while still conscious.

Tonight, respected local newspaper Dauphine Libere reported that the German's life was in danger.

A report filed at 7.20pm read: 'The state of health of the veteran driver has worsened and his condition is considered life-threatening, according to our information'.

The Dauphine is one of the most respected papers in the Alps, and has outstanding medical contacts.

An hour before, a surgeon specialising in brain and spinal injuries arrived at the hospital where Schumacher was being treated for a 'very serious' head injury.

Gerard Saillant, one of the leading neurologists in Paris and a friend of the star, was accompanied by police as he was rushed to the hospital in eastern France.

Olivier Panis, the former French F1 driver who lives in Grenoble, tried to visit his friend this evening but was turned away by the hospital authorities.

Schumacher fell while out skiing with his 14-year-old son, Mick, and other friends.

The driver's agent, Sabine Kehm, said: 'Michael fell on his head during a private ski trip in the French Alps.

'He was hospitalised and is receiving medical care. We ask for your understanding that we cannot give a running commentary on his state of health.

He was wearing a helmet and was not alone.' Schumacher, who was FI world champion seven times, was originally airlifted to nearby Moutiers following the accident, which happened just after 11am.

Christophe Gernigon-Lecomte, director of tourism in Meribel, said that two rescuers reached the sports star 'within six minutes and called a helicopter'.

The sports star was not unconscious, but clearly in a 'bad way', said Mr Gernigon-Lecomte. He said Schumacher's condition was 'not life threatening'.

He said Schumacher had been skiing 'just off piste', close to the Dent de Burgin (Tooth of Burgin) chairlift, between the Biche and Mauduit pistes.

Nobody else was involved in the accident, which is being investigated by gendarmes.

At around 1.30pm, Schumacher arrived at Grenoble hospital, which has better facilities for dealing with serious head injuries than Moutiers.

Professor Saillant is a close friend of both Schumacher and his former Ferrari team boss, Jean Todt.

Professor Saillant, an expert in brain and spinal injuries, oversaw Schumacher's medical care when the German broke his leg in the 1999 British Grand Prix.

Schumacher won the most championships race victories, fastest laps, pole positions and races in a single season.

He officially retired at the end of the 2012 season after a four-year break from the sport. He turned down the chance to drive for Lotus in the final two races of this year.

Schumacher, who turns 45 in January, has one son, and a daughter, Gina-Marie, with his wife, Corinna. The family own a chalet in Meribel.

Schumacher is a passionate and highly experienced skier. He has a piste named after him in the Italian ski resort of Madonna di Campiglio.

Conditions have been particularly dangerous in the Alps over the Christmas holidays, with a number of skiers dying in avalanches.

Mr Gernigon-Lecomte said: 'This accident is the proof that you can't do whatever you want. It's necessary to stay on the pistes, even when weather conditions are good.'

It was bright and sunny in Meribel this morning.






#mirror.co.uk

Saturday 28 December 2013

Why i ditched R&B for gospel music - Obiwon

Obiwon

Punch - The ‘Obi mu o’ crooner is known as Obiwon. His real name is Obiora Nwokolobia-Agu. In this interview, he opens up on why he ditched R&B for gospel music
 
Why did you transit from R&B to gospel?
After recording some successes on my first album, I found myself right in the thick of a celebrity/ fame lifestyle. I wasn’t yet a practising Christian but I found myself often pondering if I could possibly end up well or ever lead a good life with the way things were going. Secondly, studying the personal lives of a couple of music icons, who were my role models at the time, was scary because they all had terrible endings.  Also, things hadn’t exactly gone as planned in my career despite some successes. All these drove me to seek God and answers. Eventually, I gave my life to Christ and became born again. For me, it was first, a step of faith, as the answer to the kind of life I desired while pursuing an entertainment career.
Initially, I intended to carry on as a pop/R&B artiste, who is guided along by his faith. However, the closer I walked in the faith, the more I encountered Christ, and the clearer it was to me that He particularly desired to use my career and talent for the propagation of His gospel. I struggled a little because I had already made some gains as a secular artiste, but I did give in and I’m very glad I did.
 
How has the journey been since then?
It’s been a little more than five years ago. My second album, “The Rebirth”, was gospel although the success of the love song in it, “Obi Mu O”, almost eclipsed that fact. It was also the album that basically carried my transition and its effects, the process of trying to gain acceptance within the Christian community. I even had to leave my management team then and basically go at it by myself. However, like I always say, this wasn’t a business decision. It was about answering a call, and I’m glad I’ve received grace and inner strength to pull through.
 
It was not something you were prepared for?
I was totally not prepared for it. Due to my background, I initially used to imagine I will get to do one thing or the other sometime for my faith along the line of my career, but totally not like this. I discovered my passion for music through the pop songs I heard around me as a child. If I started early enough I would have been serving and preparing from years back…
 
Were you not scared of witnessing a drop in your fan base and do you think they have coped well with this change?
Yes, I was and that was exactly at the heart of my initial struggle. Surely, everyone will not understand it. I still get snide remarks about what informed my decision, but it’s all funny to me. It’s been more than five years now and I know where I’m going. Its part of my mission to let old followers know what happened to me and how real it is, as well as anyone else who will come across the music. I’m trusting God to do the convincing with the music.
 
Do you miss the kind of music you used to do?
Honestly, I think I sound better and make better music now than then. I think there’s been a whole lot of change in my musical skills, understanding and overall presentation. I believe that very little of it is by personal efforts. In addition to the ease that comes by inspiration, I’m also more conscious of the quality of music I put out now. Its part of my mission to change the stereotypes associated especially with Nigerian gospel music, within the resources available to me and God being my helper.
 
What’s the most fulfilling aspect of this new genre of music you have chosen?
Seeing lives changed, souls blessed and saved, certainly is most fulfilling. There’s no greater pleasure than being in God’s presence. This genre is all about the true essence of life and reaching out through it, is like saying, ‘look what I found, come experience it too. Take a step of faith and you too can discover the true essence of life and begin to walk in it.’
 
Your sophomore but first gospel album ‘the rebirth’ was released in 2009, why did it take you this long to come out with your latest effort?
It takes a process to grow fully into what I’ve been called to do; it does take a process to be able to answer boldly to some things. I would be half baked and wouldn’t be able to last long if I didn’t go through some faith experiences. For a season, it wasn’t about releasing albums, it was about learning and growing into my role.
 
What does the title of your latest effort, ‘Gold Water’ symbolise?
Water is symbolic for cleansing and restoration while Gold symbolises glory and elevation. A combination of both is the idea.
 
You are rarely seen in the social space, does this have anything to do with you new calling?
I only attend events invited to. My circles surely did change, so the events I attend mightn’t be all up in your face in the media like that. Definitely, I also only attend events now that I can either impact with my presence or that can impact me positively. It can be any type of event as long as it meets those criteria.
 
Will you do R&B once in a while if called upon and the pay is right?
R&B is a style of music; you can choose to sing either gospel with it or some other theme or message. If you are referring to ballads and love songs or other themes in my music, yes once in a while, it’s important for all to hear the faith perspective of issues in the world around us. Undoubtedly, however, the bulk of my music is God. I do have one love song in the new album dedicated to my wife, and like I already told you, pay is no longer a motivation for me.
 
Can you talk about the ‘Rebirth Band’ which you are the pioneer?
It is a bunch of dedicated young boys and girls and men who believe in my mission and principles and have come along with me to make live music as we journey on. The band first started in 2011, the name is inspired by the title of my sophomore album and I cherish their love and support.
 
Who are those you have modelled your career after in the gospel music ministry?
I do find myself in a unique position especially with how I plan to express myself in gospel music. My stronger role models aren’t musicians. However, I’ve listened a lot to Michael W.Smith, Christian Hip Hop artiste, Lecrae, Deitrick Haddon, Donnie McClurkin and Don Moen. I find their styles somewhat combining with styles of secular artistes that I used to model after while growing up in the music I make.
 
Is it possible you will surpass your hit singles like Obi Mu O and Onyinye?
Yes, but I don’t know when. They are just the beginning.
 
How is life as a husband and father?
Amazing and intriguing. I’m grateful for my home.

Human Heads in Onitsha Hotel Room: My story — Citizen Mokwe


mokwe-pix-1

Commercial activities at Old Market Road, Odoakp, Onitsha, Anambra State commenced like every other day on August 1, 2013 when, all of a sudden, some stern looking policemen arrived.

The policemen, in a commando-like manner, stormed Upper Class Hotel, located on number eight. The question on the lips of curious persons around was later answered, following the news of alleged discovery of human skulls and arms in one of the hotel rooms.

The alleged discovery led to the arrest of the owner of the hotel, Mr Bonaventure Mokwe, and some of his staff , who were whisked into the operatives waiting van which zoomed off , leaving a haze of confusion in the air.
Controversy trailed the arrest and detention of Mokwe and his staff at the Special Anti-Robbery Squad, an action that allegedly did not only violate the suspects rights but also described as not following due process. Anambra State government later joined the fray, directing the demolition of the hotel.

However, Mokwe was later granted bail by the court, but not after spending 88 days in police custody.
Describing his arrest and demolition of his hotel as a set up, the business man in the eye of the storm , during an interview with Sunday Vanguard, alleged that his ordeal could not have been unconnected with a motor park dispute between him and some Onitsha natives.

ORIGIN
Recalling the incident of August 1, 2013, Mokwe said, “ Prior to the day I was arrested and my hotel demolished on the directive of Anambra State governor , I was involved in a motor park dispute with some Onitsha natives.

“Within the period , I wrote the Obi of Onitsha three times asking him to intervene and call the natives to order but he remained understandably silent. When that failed, I wrote a petition to the Anambra State Commissioner of Police which he minuted to the Onitsha Area Commander who in turn assigned an Inspector to investigate. But these efforts ended as soon as they started”.

He narrated further: “When that failed again, I went to court and obtained an order which was served on the palace of Obi of Onitsha, the police and leaders of the Onitsha natives antagonising me. Soon after some bus drivers started loading in my park and all hell broke loose, as threats of all dimension started coming from the Onitsha natives which culminated in the planting of the exhibits in my hotel. The human skulls and magazines were parked in a sac and planted in the wardrobe at my hotel lodging room number 102.

“ I drove into my office around 7am that fateful day because I had a land transaction. Before I could settle down, my hotel was surrounded by the police numbering over 100. As I made my way towards my office entrance, some of them were already in the passage. I was taken into my office and shown a search warrant.

“ In the process, one police officer betrayed the whole adventure when he shouted at one of my staff to be shown room 102. It did not make sense to me then. The first thing I saw when the door of the room was opened was an unsealed traveling bag on the floor. Some polythene bags were inside the bag and two on the bed. Nothing was found in the toilet and under the bed. The police then opened the wardrobe of the room and brought out one single Bagco sac, in which were two rotten skulls, two A.K 47 riffles that looked unserviceable and two loaded magazines.

“The mock search exercise started and ended after five minutes or thereabouts at the door of room 102 . Incidentally the lodger locked the room and left with the key around 6.30am, following which the police showed up.
“The manager informed the police that the room was sold to one Mr John Obi, in the evening of 31st of July, 2013.

The receptionist brought the duplicate of the lodging receipt in addition to the hotel guest manifest and both reflected John Obi as the occupant at room 102. It is important to point out that the hotel guest manifest had earlier been submitted at the police station before the arrival of the policemen to the hotel. This has been the routine for some time now.

I was immediately handcuffed and taken outside the corridor of the hotel, where I was told to sit next to the exhibits while they took pictures. Soon after that, I, alongside my staff, was taken to the police Area Command Onitsha and paraded before the public and journalists.



CONFESSION
“We were subsequently taken to SARS Awkuzu, along with my wife who is a lawyer, and detained. At SARS, the identity of the person that lodged in my hotel room number 102 on the very day the police came searching was unmasked. Though he gave his name as John Obi, his true identity was that of a native of Umudie village. His picture was smuggled and shown to the receptionist who identified him as the person he gave the receipt of room 102 that fateful day. It was him who planted the exhibits in the hotel room wardrobe.

“I almost died in the first two to three days at SARS. Any confessional statement emanating from SARS Awkuzu is a function of an individual’s pain threshold. In effect, an innocent person can be a casualty of any sort. While informants are very important in police work, being able to know when a particular informant collects money to set-up another person’s rival as in this case of mine is also critical.

IDENTITY
“When the identity of the people that orchestrated my hotel set-up became known even by the general public, a petition was written by my lawyer to the Inspector-General of Police, listing their names. But the police sat on it because arresting them would have meant releasing me and that would have meant a state financial liability and embarrassment for the state government.

With the police under pressure from the media , most especially by NIPPRON, I, along with three of my staff, was arraigned in court on the 17th of October 2013 and a murder charge along with possession of human skulls and fire arms were heaped on us and we were subsequently remanded in prison till 4th of November 2014 when we were granted bail. I spent a total of two months and seventeen days at SARS Awkuzu.

ROTTEN SKULLS
“A week after I arrived from SARs, it became increasingly clear that the incident was a set-up. Matters were not helped by what occurred when the police first took me to the grave of one Mr Nwonye Akas, a native of Nkwuele Ezinaka Itite village, who died in 1972 when I was still running around naked, only for them to say I killed and buried the man at the place.

“What is my business with rotten skulls? The police has some questions to answer; why did they not make attempt to arrest the person that lodged in the room, despite the fact that guests manifesto was sent to them? If it was real, the person who stayed in the hotel room should have been apprehended. It would then be for him to reveal who gave him the thing because there is no way he could have slept in that room with all those things without knowing.

“Again, the true reason my hotel was speedily demolished within hours of my arrest by the state government without informing the police command is also in custody of my lawyers. All these will be made public when the need arises .

My hotel demolition had nothing to do with fighting crime, as it was sold to the general public. Till date, there is no complaint irrespective of police efforts in manufacturing one in their bid to cover up for the Anambra State government from its self-inflicted liability.

Details of how the murder charged was framed was blown in the prison including a tape recording of it.
“When I was bailed, a legal officer with Anambra State government begged my cousin to tell me to lie low until after the elections. I obeyed. So you can see that it’s not all about justice, it’s about what they can gain from it. They told me to lie low that after electioneering campaign, something would be done to address the issue, but till date nothing has been done.

JUSTICE
The state government should sit with my lawyer or appoint someone to sit with my lawyer and agree on how to pay for the damages. You don’t beat somebody and tell him not to cry. Secondly, this matter is impossible to wish away. No amount of prayer will wish it away. I must be paid everything. Everything I had was destroyed, including my Green Card, in that hotel building.

Those fabricated charges should be cancelled because they are mere damage control charges intended to fill in the blanks, they have no bearing on me because they were manufactured. You don’t charge one for possession when you didn’t see anything on him. Also , you don’t charge someone for murder when investigation has not been done.”





#vanguard