Shoppers at a Tesco Extra store will be able to have a free HIV test.
The shop is setting aside a room for six weeks from Monday so that a sexual health organisation can do the tests.
The charity will also give out free condoms.
Sarah Macadam, boss of Thames Valley Positive Support, said: “We want tonormalise HIV testing and the best way to do that is in everyday environments.
“We would like to branch out into leisure centres, gyms and other shops.”
Customers will be offered a pinprick test, which gives results in 60 seconds. An alternative oral swab has an outcome in 20 minutes.
The trial in Slough, Berks, will continue if successful.
In November, a free HIV testing clinic opened in a Baptist church in Walthamstow, East London.

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